Despite the implementation of increasingly aggressive surgery, chemotherapy, and fractionated radiotherapy for the treatment of glioblastoma multiforme (GBM), most therapeutic regimens have resulted in only modest improvements in patient survival.The goal of GBM treatment cannot realistically be the eradication of the tumor but rather striking a balance between increasing the length of survival and maintaining an acceptable quality of life for the patient.

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 Different treatment regimens (for example, the use of GKS to provide post-EBRT boost or at time of recurrence) and treatment options for patients who have undergone gross-total resection are beneficial. The rationale for such investigations is provided by numerous institutional reviews that demonstrate a life-prolonging effect of GKS in the management of GBM . Some institutes administer GKS at the time of tumor recurrence or give a scheduled GKS boost within 4 weeks of the completion of EBRT. The Gamma Knife takes advantage of the natural difference in susceptibility of pathological and normal tissue. The relative radioresistance of normal brain tissue is the result of its low mitotic activity.

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